Helicobacter pylori (H. pylori) causes gastritis, which has been attributed to the development of H. pylori-specific T cells during infection. However, the mechanism underlying innate immune detection leading to the priming of T cells is not fully understood, as H. pylori evades TLR detection.

The research group of Sho Yamasaki (Molecular Immunology, IFReC/RIMD, Osaka University) revealed H. pylori metabolites modified from host cholesterol exacerbate gastritis through the interaction with C-type lectin receptors.

Article (External Link)

Contact:

Sho Yamasaki(Molecular Immunology)

+81-6-6879-8306
yamasakibiken.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)