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HOME > News & Topics > Research > FY 2021 > The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis (Takeda G, in PNAS)

The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis (Takeda G, in PNAS)

Hisako Kayama (the Institute for Advanced Co-Creation Studies/IFReC), Kiyoshi Takeda (IFReC/Graduate School of Medicine, Osaka University) and their research group showed that E-NTPD8 is highly expressed in large intestinal epithelial cells and hydrolyzes microbiota-derived luminal ATP.

 figure E-NTPD8 prevents neutrophil-mediated colitis by hydrolyzing luminal ATP.
E-NTPD8 in colonic epithelial cells maintains the gut homeostasis through hydrolysis of luminal ATP produced by commensal bacteria (left). An increased level of luminal ATP caused by lack of E-NTPD8 modulates neutrophil physiology, such as prolonged survival, through P2X4-mediated promotion of glycolysis, which links to aggravation of colitis (right).



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Kiyoshi Takeda

Kiyoshi Takeda(Mucosal Immunology)


Tel+81-6-6879-3980
Mail ktakedaongene.med.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)

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