News & Topics
The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis (Takeda G, in PNAS)
Hisako Kayama (the Institute for Advanced Co-Creation Studies/IFReC), Kiyoshi Takeda (IFReC/Graduate School of Medicine, Osaka University) and their research group showed that E-NTPD8 is highly expressed in large intestinal epithelial cells and hydrolyzes microbiota-derived luminal ATP.
E-NTPD8 prevents neutrophil-mediated colitis by hydrolyzing luminal ATP.
E-NTPD8 in colonic epithelial cells maintains the gut homeostasis through hydrolysis of luminal ATP produced by commensal bacteria (left). An increased level of luminal ATP caused by lack of E-NTPD8 modulates neutrophil physiology, such as prolonged survival, through P2X4-mediated promotion of glycolysis, which links to aggravation of colitis (right).
Commentary(PDF)
Article (External Link)
Contact:
Kiyoshi Takeda(Mucosal Immunology)
+81-6-6879-3980
ktakeda@ongene.med.osaka-u.ac.jp