A research group led by Professor Hisashi Arase (IFReC/RIMD/CiDER, Osaka University) together with Kyoto University, Kobe Central City Hospital, and RIKEN elucidated a new pathogenic mechanism of systemic lupus erythematosus.

Figure:
In general, immunization of DNA alone does not produce anti-DNA antibodies in mice. The group showed the expression of DNA by HLA class II molecules and stimulation of DNA reactive BCR by DNA/HLA class II complex. Then it may lead the B cell-T cell interaction and production of anti-DNA Abs.

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Hisashi Arase (Immunochemistry)

+81-6-6879-8291
arasebiken.osaka-u.ac.jp
WPI Osaka University Immunology Frontier Research Center