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HOME > News & Topics > Research > FY 2021 > New Pathogenic Mechanism of Systemic Lupus Erythematosus (Arase G, in Arthritis Rheumatol.)

New Pathogenic Mechanism of Systemic Lupus Erythematosus (Arase G, in Arthritis Rheumatol.)

A research group led by Professor Hisashi Arase (IFReC/RIMD/CiDER, Osaka University) together with Kyoto University, Kobe Central City Hospital, and RIKEN elucidated a new pathogenic mechanism of systemic lupus erythematosus.

Figure:
In general, immunization of DNA alone does not produce anti-DNA antibodies in mice. The group showed the expression of DNA by HLA class II molecules and stimulation of DNA reactive BCR by DNA/HLA class II complex. Then it may lead the B cell-T cell interaction and production of anti-DNA Abs.


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Contact:
Hisashi Arase

Hisashi Arase (Immunochemistry)

Tel+81-6-6879-8291
Mail arase@biken.osaka-u.ac.jp
WPI Osaka University Immunology Frontier Research Center

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