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Aggravation of Th1-mediated colitis by LysoPS (Takeda G, in JEM)

Crohn's disease is a chronic gastrointestinal tract disorder with transmural inflammation with unknown etiology. Hisako Kayama, Kiyoshi Takeda (IFReC/Graduate School of Medicine, Osaka University), and the research group showed a key metabolite LysoPS derived from dysbiotic microbiota enhances Th1 responses and exaggerate colitis in mouse models.

 figure Elevation of intestinal lysophosphatidylserine (LysoPS) concentration due to microbial phospholipase A (PLA)-mediated hydrolysis of phosphatidylserine in the host cell membrane in patients with Crohn's disease causes progression of intestinal inflammation by eliciting immunopathological Th1 responses through promotion of glycolysis via P2Y10 receptor.

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Kiyoshi Takeda

Kiyoshi Takeda(Mucosal Immunology)


Immunology Frontier Research Center, Osaka University (WPI-IFReC)