Crohn's disease is a chronic gastrointestinal tract disorder with transmural inflammation with unknown etiology. Hisako Kayama, Kiyoshi Takeda (IFReC/Graduate School of Medicine, Osaka University), and the research group showed a key metabolite LysoPS derived from dysbiotic microbiota enhances Th1 responses and exaggerate colitis in mouse models.

　 Elevation of intestinal lysophosphatidylserine (LysoPS) concentration due to microbial phospholipase A (PLA)-mediated hydrolysis of phosphatidylserine in the host cell membrane in patients with Crohn's disease causes progression of intestinal inflammation by eliciting immunopathological Th1 responses through promotion of glycolysis via P2Y10 receptor.

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Kiyoshi Takeda（Mucosal Immunology）

+81-6-6879-3980
ktakedaongene.med.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)