In bone marrow, special microenvironments, known as niches, are essential for the maintenance of hematopoietic stem cells (HSCs).
Yoshiki Omatsu, Takashi Nagasawa (Stem Cell Biology and Developmental Immunology, IFReC/Graduate School of Frontier Biosciences, Osaka University) and the research group showed HSC cellular niches require Runx1 or Runx2 to prevent their fibrotic conversion and maintain HSCs and hematopoiesis in adults.

Figure.
CAR cells are specialized mesenchymal stem cells, which express the specific transcription factors,
including Runx1/2 as well as Foxc1 and Ebf1/3. Runx1/2 prevents fibrotic conversion of CAR cells to maintain HSC niches.

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Contact:

Takashi Nagasawa（Stem Cell Biology and Developmental Immunology）

06-6879-4953
tnagasafbs.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)