Many plasma cells die shortly after participating in an immune response, but a small population of plasma cells called long-lived plasma cells (LLPCs) can survive in the body for months or even years. The research group of Wataru Ise (CiDER) and TomohiroKurosaki (IFReC) found that plasma cells were continuously replenished by new cells, a small portion of which differentiated into long-lived plasma cells (LLPCs).

Fig. 1:
Most of plasma cells that arrive at bone marrow are short-lived B220(hi) MHC-II(hi) cells. A small fraction of them become immobilized to bone marrow niches and progressively differentiate into long-lived B220(lo) MHC-II(lo) cells.

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