Gaucher's disease is a disease develops due to the systemic accumulation of glucosylceramide. Althogh the disorders of central nervous system are particularly severe, the detailed molecular mechanisms are unknown and there are no effective treatments.
The research group led by Sho Yamasaki (RIMD, IFReC, CiDER, and CAMaD) revealed the direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease.

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Sho Yamasaki(Molecular Immunology)

+81-6-6879-8306
yamasakibiken.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)

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Sho Yamasaki Lab.

yamasakibiken.osaka-u.ac.jp

Molecular Immunology