Tadamitsu Kishimoto group (Immune Regulation) revealed an inhibitory mechanism of Lenalidomide (thalidomide derivatives) on inflammatory immune responses. It is known that the drug thalidomide has an inhibitory effect on production of inflammatory cytokines such as TNF-α, IL-6 and interferon. In this study, they showed that 1) Rabex-5, which is known as an inhibitor of inflammatory cytokine productions, binds to Cereblon, 2) thalidomide derivatives release Rabex5 from its binding to Cereblon, and 3) Rabex-5 regulates TLR-induced cytokine and type 1 interferon production.

Contact:
Tadamitsu Kishimoto
Immune Regulation
Immunology Frontier Research Center (WPI-IFReC), Osaka University