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B-1a lymphocytes promote oligodendrogenesis during brain development (Yamashita Group, in Nature Neuroscience)

Toshihide Yamashita (Molecular Neuroscience, IFReC) and his research group showed the most abundant infiltrating lymphocytes in the developing brain are B cells.

Figure1 Schematic diagram of the study
B-1a cells in meningeal space secrete natural antibodies,
which promote the proliferation of oligodendrocyte precorsors.
With this mechanism, B-1a cells support the brain development.



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Contact:
Toshihide Yamashita

Toshihide Yamashita(Molecular Neuroscience)


Tel+81-6-6879-3971
Mailyamashitamolneu.med.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)

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