The lipopolysaccharide (LPS)-induced endocytosis of Toll-like receptor 4 (TLR4) is an essential step in the production of interferon-β (IFN-β), which activates the transcription of antiviral response genes by STAT1 phosphorylated at Tyr701.
Hozaifa Saad Hassan Metwally, Tadamitsu Kishimoto (Immune Regulation, IFReC) and the research group showed that noncanonical phosphorylation in response to LPS confers STAT1 with distinct DNA binding and gene-regulatory properties that promote both IL12B expression and IL6 mRNA stabilization. Their study provides a potential mechanism for how TLR4 endocytosis regulate proinflammatory cytokine production.

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Contact:

Tadamitsu Kishimoto (Immune Regulation)

+81-6-6879-4956
kishimoto@ifrec.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)