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HOME > News & Topics > Research > FY 2020 > Tet2 and Tet3 in B cells repress CD86 and prevent autoimmunity (Kurosaki G, in Nat Immunol)​

Tet2 and Tet3 in B cells repress CD86 and prevent autoimmunity (Kurosaki G, in Nat Immunol)​

Wataru Ise, Tomohiro Kurosaki (Lymphocyte Differentiation, IFReC), Shinya Tanaka, Yoshihiro Baba (Kyushu University) and their research group reported that deficiency of ten-eleven translocation (Tet) DNA demethylase family members, Tet2 and Tet3, in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease.​​

Tet分子による自己寛容制御Tet-mediated B cell tolerance
Tet2/3-deficient B cells are activated by self-antigen and express exaggerated amount of CD86.
Then those B cells stimulate autoreactive CD4+ T cells, resulting in autoimmune response.




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Lymphocyte Differentiation Tomohiro Kurosaki

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WPI Osaka University Immunology Frontier Research Center

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