Wataru Ise, Tomohiro Kurosaki (Lymphocyte Differentiation, IFReC), Shinya Tanaka, Yoshihiro Baba (Kyushu University) and their research group reported that deficiency of ten-eleven translocation (Tet) DNA demethylase family members, Tet2 and Tet3, in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease.​​

Tet-mediated B cell tolerance
Tet2/3-deficient B cells are activated by self-antigen and express exaggerated amount of CD86.
Then those B cells stimulate autoreactive CD4+ T cells, resulting in autoimmune response.

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Contact:

Tomohiro Kurosaki（Lymphocyte Differentiation）

+81-6-6879-4456
kurosakiifrec.osaka-u.ac.jp

WPI Osaka University Immunology Frontier Research Center