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A novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells (Yamamoto G, in JEM)

Masahiro Yamamoto (Immunoparasitology, IFReC/RIMD, Osaka University) and his research group show that TCR signaling in CD8+ T cells is qualitatively different from that in CD4+ T cells, since CD8α ignites another cardinal signaling cascade involving phospholipase C β4 (PLCβ4).

toxoplasma, cancer immunity, CTLC, PLCβ4

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Masahiro Yamamoto

Masahiro Yamamoto (Immunoparasitology)


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