Although the Ragulator complex is required for cell migration, the mechanisms by which it participates in cell motility remain unknown. Hyota Takamatsu, Atsushi Kumanogoh (Immunopathology, IFReC & Graduate School of Medicine, Osaka University), and their research group showed that the lysosomal Ragulator complex plays an essential role in leukocyte migration by activating myosin II. ​​​

Schematic of the mechanism of regulation of myosin II activity by the Ragulator complex.

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Contact:

Atsushi Kumanogoh(Immunopathology)

Immunology Frontier Research Center, Osaka University (WPI-IFReC)