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The lysosomal Ragulator is necessary for leukocyte trafficking (Kumanogoh G, in Nat Commun)

Although the Ragulator complex is required for cell migration, the mechanisms by which it participates in cell motility remain unknown. Hyota Takamatsu, Atsushi Kumanogoh (Immunopathology, IFReC & Graduate School of Medicine, Osaka University), and their research group showed that the lysosomal Ragulator complex plays an essential role in leukocyte migration by activating myosin II. ​​​

Schematic of the mechanism of regulation of myosin II activity by the Ragulator complex.

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Contact:
Atsushi Kumanogoh

Atsushi Kumanogoh(Immunopathology)


Immunology Frontier Research Center, Osaka University (WPI-IFReC)

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