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Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion (Hara G, in Nat Commun)

Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC).
The research group of Eiji Hara (Aging Biology, IFReC/RIMD Osaka University) showed that 12 faecal bacterial taxa are enriched in CRC patients. Among them, 2 Porphyromonas species are capable of inducing cellular senescence, an oncogenic stress response, through the secretion of the bacterial metabolite, butyrate.

Gut microbiome analysis Figure: Gut microbiome analysis.
Twelve bacterial taxa that were abundant in CRC patients and rarely present in healthy individuals were identified.



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Eiji Hara

Eiji Hara(Aging Biology)


Tel+81-6-6879-4261
Mail eharabiken.osaka-u.ac.jp

WPI Immunology Frontier Research Center (WPI-IFReC)

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