Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC).
The research group of Eiji Hara (Aging Biology, IFReC/RIMD Osaka University) showed that 12 faecal bacterial taxa are enriched in CRC patients. Among them, 2 Porphyromonas species are capable of inducing cellular senescence, an oncogenic stress response, through the secretion of the bacterial metabolite, butyrate.

Figure: Gut microbiome analysis.
Twelve bacterial taxa that were abundant in CRC patients and rarely present in healthy individuals were identified.

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Eiji Hara（Aging Biology）

+81-6-6879-4261
eharabiken.osaka-u.ac.jp

WPI Immunology Frontier Research Center (WPI-IFReC)