Yuki Ochiai, Katsumori Segawa (present: Tokyo Medical and Dental University), Shigekazu Nagata (Biochemistry & Immunology, IFReC), and the research group showed that a flippase Atp11a at the plasma membrane plays an important role in the formation of syncytiotrophoblasts in placental development.

Figure 1.
Embryonic lethality of Atp11a-/- mice. Atp11a-/- mouse embryos died at E14.5 with thin-walled heart ventricles.
However, the cardiomyocyte- or epiblast-specific Atp11a deletion did not affect mouse development,
suggesting the inability of Atp11a-/- placentas to support the embryos.

Commentary (PDF)


Article (External Link)

Contact:

Shigekazu Nagata (Biochemistry & Immunology)

+81-6-6879-4953
snagataifrec.osaka-u.ac.jp

Immunology Frontier Research Center, Osaka University (WPI-IFReC)